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Aug 21, 20251 sourceGPT-4b microOpenAI64K contextLicense not discloseddeveloped for research purposes; not broadly available
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What we captured
OpenAI describes GPT‑4b micro, an experimental GPT model trained for protein engineering and developed for research purposes (not broadly available); the model can handle prompts up to 64,000 tokens and was used with Retro Biosciences to design enhanced protein variants.
- • Source (Aug 22, 2025): 'we collaborated with the Applied AI team at Retro Bio... to create and research the impact of GPT‑4b micro, a miniature version of GPT‑4o specialized for protein engineering.'
- • Source: 'GPT‑4b micro was developed for research purposes and is not broadly available.'
- • Source: 'we could run prompts as large as 64,000 tokens during inference' (article states this context size was used during development/inference).
- • Source: OpenAI reports GPT‑4b micro was used with Retro Biosciences to design RetroSOX and RetroKLF variants that in vitro 'achieved greater than a 50-fold higher expression of stem cell reprogramming markers than wild-type controls.'
- • Article publication date: 2025-08-22.